Identification of porphyrin modified photosensitizer porfimer sodium and its precursors by high performance liquid chromatography and mass spectrometry.

@article{Stoev2007IdentificationOP,
  title={Identification of porphyrin modified photosensitizer porfimer sodium and its precursors by high performance liquid chromatography and mass spectrometry.},
  author={Georgi Stoev and Al Stoyanov and Maria Shopova and Kr Dachev},
  journal={Journal of chromatography. A},
  year={2007},
  volume={1145 1-2},
  pages={
          141-8
        }
}
Photodit (porfimer sodium) is a complex mixture of porphyrin-modified oligomers that has demonstrated high photoactivity during photodynamic therapy of malignant tumors. Hematoporphyrin derivative monomer precursors of Photodit and its oligomers were analyzed using liquid chromatography and mass spectrometry to determine their chemical composition and structures. Hematoporphyrin (M-3), O,O'-diacetylhematoporphyrin (M-6), and isomers of 8(-3)-hydroxyethyl-3(-8)-vinyldeuteroporphyrin (M-2), 8(-3… CONTINUE READING