Identification of porcine endothelial cell membrane antigens recognized by human xenoreactive natural antibodies.

@article{Holzknecht1995IdentificationOP,
  title={Identification of porcine endothelial cell membrane antigens recognized by human xenoreactive natural antibodies.},
  author={Zoie E. Holzknecht and Jeffrey L Platt},
  journal={Journal of immunology},
  year={1995},
  volume={154 9},
  pages={4565-75}
}
Rejection of an organ transplanted into a phylogenetically disparate recipient may be initiated by the binding of xenoreactive natural Abs of the recipient to Ags expressed on donor endothelium leading to the activation of the C system. Having previously shown that human xenoreactive Abs bind predominantly to N-linked oligosaccharides on porcine endothelial cell glycoproteins, we sought to identify those glycoproteins to gain insight into the pathogenesis of the rejection reaction and to… CONTINUE READING

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