Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene.

@article{Liu1995IdentificationOP,
  title={Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene.},
  author={Juanyin Liu and Tatsushi Fujiwara and Natalie T. Buu and Fernando Orozco S{\'a}nchez and Mathieu F. M. Cellier and Alan J. Paradis and Danielle Frappier and Emil Skamene and Piet Gros and Kenneth J. Morgan},
  journal={American journal of human genetics},
  year={1995},
  volume={56 4},
  pages={
          845-53
        }
}
The most common mycobacterial disease in humans is tuberculosis, and there is evidence for genetic factors in susceptibility to tuberculosis. In the mouse, the Bcg gene controls macrophage priming for activation and is a major gene for susceptibility to infection with mycobacteria. A candidate gene for Bcg was identified by positional cloning and was designated "natural resistance-associated macrophage protein gene" (Nramp1), and the human homologue (NRAMP1) has recently been cloned. Here we… CONTINUE READING

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