Identification of poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax protein.

@article{Anderson2000IdentificationOP,
  title={Identification of poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax protein.},
  author={Mark G. Anderson and Kirsten E. S. Scoggin and Cynthia Marie Simbulan-Rosenthal and Jennifer A. Steadman},
  journal={Journal of virology},
  year={2000},
  volume={74 5},
  pages={2169-77}
}
Human T-cell leukemia virus type 1 (HTLV-1) encodes a transcriptional activator, Tax, whose activity is believed to contribute significantly to cellular transformation. Tax stimulates transcription from the proviral promoter as well as from promoters for a variety of cellular genes. The mechanism through which Tax communicates to the general transcription factors and RNA polymerase II has not been completely determined. We investigated whether Tax could function directly through the general… CONTINUE READING
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