Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry.

Abstract

Vasopressin-mediated control of water permeability in the renal collecting duct occurs in part through regulation of the distribution of aquaporin-2 (AQP2) between the apical plasma membrane and intracellular membrane compartments. Phosphorylation of Ser-256 at AQP2's cytoplasmic COOH-terminus is well-accepted as a critical step for translocation. The aim… (More)
DOI: 10.1021/pr800894p

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