Identification of phenobarbitone-modulated genes in mouse liver by differential display.

@article{GarciaAllan2000IdentificationOP,
  title={Identification of phenobarbitone-modulated genes in mouse liver by differential display.},
  author={C. Garcia-Allan and Peter G. Lord and Jeanne Loughlin and Terry C. Orton and J E Sidaway},
  journal={Journal of biochemical and molecular toxicology},
  year={2000},
  volume={14 2},
  pages={
          65-72
        }
}
The molecular basis of how rodent nongenotoxic hepatocarcinogens such as phenobarbitone cause liver-tumor formation is poorly understood. An early effect of phenobarbitone exposure is to induce hepatocyte proliferation transiently, and there is evidence that this may be important for subsequent tumor development. In this investigation, we have used the differential display reverse transcriptase polymerase chain reaction technique to analyze differential gene expression in male C57B1/10J mouse… CONTINUE READING