Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities.

@article{Nahomi2015IdentificationOP,
  title={Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities.},
  author={Rooban B. Nahomi and Michael A. DiMauro and Benlian Wang and Ram H Nagaraj},
  journal={The Biochemical journal},
  year={2015},
  volume={465 1},
  pages={115-25}
}
Previous studies have identified peptides in the 'crystallin-domain' of the small heat-shock protein (sHSP) α-crystallin with chaperone and anti-apoptotic activities. We found that peptides in heat-shock protein Hsp20 (G71HFSVLLDVKHFSPEEIAVK91) and Hsp27 (D93RWRVSLDVNHFAPDELTVK113) with sequence homology to α-crystallin also have robust chaperone and anti-apoptotic activities. Both peptides inhibited hyperthermic and chemically induced aggregation of client proteins. The scrambled peptides of… CONTINUE READING

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