Identification of peptide substrates for human MMP-11 (stromelysin-3) using phage display.

  title={Identification of peptide substrates for human MMP-11 (stromelysin-3) using phage display.},
  author={Weijun Pan and Marc R. Arnone and Marvin Kendall and Robert H. Grafstrom and Steven P. Seitz and Zelda R. Wasserman and Charles F. Albright},
  journal={The Journal of biological chemistry},
  volume={278 30},
The MMP-11 proteinase, also known as stromelysin-3, probably plays an important role in human cancer because MMP-11 is frequently overexpressed in human tumors and MMP-11 levels affect tumorogenesis in mice. Unlike other MMPs, however, human MMP-11 does not cleave extracellular matrix proteins, such as collagen, laminin, fibronectin, and elastin. To help identify physiologic MMP-11 substrates, a phage display library was used to find peptide substrates for MMP-11. One class of peptides… CONTINUE READING


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