Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins.

@article{Couet1997IdentificationOP,
  title={Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins.},
  author={Jacques Couet and Shu-xia Li and Tetsugaku Okamoto and Tsuneya Ikezu and Michael p. Lisanti},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 10},
  pages={
          6525-33
        }
}
Caveolin, a 21-24-kDa integral membrane protein, is a principal component of caveolae membranes. We have suggested that caveolin functions as a scaffolding protein to organize and concentrate certain caveolin-interacting proteins within caveolae membranes. In this regard, caveolin co-purifies with a variety of lipid-modified signaling molecules, including G-proteins, Src-like kinases, Ha-Ras, and eNOS. Using several independent approaches, it has been shown that a 20-amino acid membrane… CONTINUE READING

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