Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection.

@article{Fonseca2005IdentificationOP,
  title={Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection.},
  author={Cristina T Fonseca and Edecio Cunha-Neto and Anna Carla Goldberg and Jorge Kalil and Am{\'e}lia Maria Ribeiro de Jesus and Edgard Marceiino Carvalho and Rodrigo Corr{\^e}a-Oliveira and J{\"u}rgen Hammer and John Sidney and Alessandro Sette and Sergio Costa Oliveira},
  journal={Clinical and experimental immunology},
  year={2005},
  volume={142 3},
  pages={
          539-47
        }
}
Paramyosin, a Schistosoma mansoni myoprotein associated with human resistance to infection and reinfection, is a candidate antigen to compose a subunit vaccine against schistosomiasis. In this study, 11 paramyosin peptides selected by TEPITOPE algorithm as promiscuous epitopes were produced synthetically and tested in proliferation and in vitro human leucocyte antigen (HLA)-DR binding assays. A differential proliferative response was observed in individuals resistant to reinfection compared to… CONTINUE READING
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