Identification of p90, a prominent tyrosine-phosphorylated protein in fibroblast growth factor-stimulated cells, as 80K-H.

@article{Goh1996IdentificationOP,
  title={Identification of p90, a prominent tyrosine-phosphorylated protein in fibroblast growth factor-stimulated cells, as 80K-H.},
  author={Kee Chuan. Goh and Yoon Pin Lim and Siew Hwa Ong and C B Siak and Xinwang Cao and Yves S H Tan and Graeme Roy Guy},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 10},
  pages={
          5832-8
        }
}
Tyrosine phosphorylation of cellular proteins occurs rapidly upon treatment of fibroblasts with acidic or basic fibroblast growth factors (aFGF, bFGF), suggesting a role for protein phosphorylation in the FGF signaling pathway. Stimulation of Swiss 3T3 cells and MRC-5 fibroblasts with bFGF results in the tyrosine phosphorylation of several proteins, of which the most prominent has been designated as p90. The phosphorylation of p90 is observed within 30 s of treating the cells with FGF but not… CONTINUE READING

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