Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1 (Hypermethylated In Cancer 1).

@article{Dehennaut2013IdentificationOP,
  title={Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1 (Hypermethylated In Cancer 1).},
  author={Vanessa Dehennaut and Ingrid Loison and Gaylor Boulay and Capucine Van Rechem and Dominique Leprince},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={430 1},
  pages={49-53}
}
The tumor suppressor gene HIC1 (Hypermethylated In Cancer 1) encodes a transcriptional repressor involved in the regulation of growth control and DNA damage response. We previously demonstrated that p57Kip2; a member of the CIP/KIP family of CDK (cyclin dependent kinase) inhibitors (CKI); is a direct target gene of HIC1 in quiescent cells. Here we show that… CONTINUE READING