Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3).

@article{Wada2008IdentificationOO,
  title={Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3).},
  author={Taira Wada and Hong Soon Kang and Martin Angers and Haibiao Gong and Shikha Bhatia and S. E. Khadem and Songrong Ren and Ewa C S Ellis and Stephen C Strom and Anton M Jetten and Wen Xie},
  journal={Molecular pharmacology},
  year={2008},
  volume={73 3},
  pages={
          891-9
        }
}
The retinoid-related orphan receptors (RORs) and liver X receptors (LXRs) were postulated to have distinct functions. RORs play a role in tissue development and circadian rhythm, whereas LXRs are sterol sensors that affect lipid homeostasis. In this study, we revealed a novel function of RORalpha (NR1F1) in regulating the oxysterol 7alpha-hydroxylase (Cyp7b1), an enzyme critical for the homeostasis of cholesterol, bile acids, and oxysterols. The expression of Cyp7b1 gene was suppressed in the… CONTINUE READING

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