Identification of osteopontin in human dental calculus matrix.

  title={Identification of osteopontin in human dental calculus matrix.},
  author={Jun-ichi Kido and Chika Kasahara and Kazuo Ohishi and Sumio Nishikawa and Hajime Ishida and Kazuo Yamashita and Seiichiro Kitamura and Kazuhiro Kohri and Toshihiko Nagata},
  journal={Archives of oral biology},
  volume={40 10},
Osteopontin is a prominent non-collagenous component of bone matrix, although it is expressed in several other tissues. Recently, osteopontin was reported to be involved in urinary stone formation and atherosclerotic lesions of the aorta, suggesting that it may be a key protein associated with these types of pathological mineralization. In this study, whether or not human dental calculus contains osteopontin was investigated by immunoblotting and immunohistochemical analyses. After extraction… CONTINUE READING