Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis.

Abstract

Epithelio-mesenchymal interactions during kidney organogenesis are disrupted in integrin alpha8 beta1-deficient mice. However, the known ligands for integrin alpha8 beta1-fibronectin, vitronectin, and tenascin-C-are not appropriately localized to mediate all alpha8 beta1 functions in the kidney. Using a method of general utility for determining the… (More)

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@article{Denda1998IdentificationOO, title={Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis.}, author={Sadahei Denda and Lars Reichardt and Ulrich Alfons M{\"u}ller}, journal={Molecular biology of the cell}, year={1998}, volume={9 6}, pages={1425-35} }