Identification of osteoblast stimulating factor 5 as a negative regulator in the B-lymphopoietic niche.

@article{Fujita2015IdentificationOO,
  title={Identification of osteoblast stimulating factor 5 as a negative regulator in the B-lymphopoietic niche.},
  author={Natsuko Fujita and Michiko Ichii and Tetsuo Maeda and Norimitsu Saitoh and Takafumi Yokota and Kengo Yamawaki and Makoto Kakitani and Kazuma Tomizuka and Kenji Oritani and Yuzuru Kanakura},
  journal={Experimental hematology},
  year={2015},
  volume={43 11},
  pages={963-973.e4}
}
Recent studies have revealed the crucial role of the niche which supports B-lymphocyte differentiation from hematopoietic stem cells. In this study, we aimed to identify a novel regulator of B lymphopoiesis secreted in the specific niche using the signal sequence trap method. Among the identified proteins from MS5 stromal cells, expression of pleiotrophin, placental proliferin 2, and osteoblast stimulating factor 5 (OSF-5) was dominantly high in several stromal cell lines. We found that OSF-5… CONTINUE READING
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