Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family.

@article{Pandey2002IdentificationOO,
  title={Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family.},
  author={Anjali Pandey and Deborah L Volkots and Joseph M Seroogy and Jack W Rose and Jin-Chen Yu and Joseph L. Lambing and Athiwat Hutchaleelaha and Stanley J. Hollenbach and Keith Abe and Neill A. Giese and Robert Murry Scarborough},
  journal={Journal of medicinal chemistry},
  year={2002},
  volume={45 17},
  pages={
          3772-93
        }
}
We have previously found that the 4-[4-(N-substituted carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazolines can function as potent and selective inhibitors of platelet-derived growth factor receptor (PDGFR) phosphorylation. A series of highly potent, specific, orally active, small molecule kinase inhibitors directed against members of PDGFR receptor have been developed through modifications of the novel quinazoline template I. Systematic modifications in the A-bicyclic ring and D-rings of protype… CONTINUE READING
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