Identification of operationally overlapping and independent cross-reactive neutralization regions on human rotavirus VP4.

@article{Kobayashi1990IdentificationOO,
  title={Identification of operationally overlapping and independent cross-reactive neutralization regions on human rotavirus VP4.},
  author={Nobumichi Kobayashi and Koki Taniguchi and Shozo Urasawa},
  journal={The Journal of general virology},
  year={1990},
  volume={71 ( Pt 11)},
  pages={2615-23}
}
Cross-reactive neutralization epitopes on VP4 of human rotavirus (HRV) were analyzed by the use of VP4-specific neutralizing monoclonal antibodies (N-MAbs) and MAb-resistant mutants. Seven anti-VP4 N-MAbs obtained in this study by using HRV serotypes 1 and 3 as immunizing antigens showed a variety of cross-reactivity patterns to 20 HRV strains with different serotype specificity in neutralization tests and a broader cross-reactivity to them was found for four N-MAbs in an enzyme-linked… CONTINUE READING

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