Identification of one or two α-globin gene deletions by isoelectric focusing electrophoresis.

@article{Agarwal2013IdentificationOO,
  title={Identification of one or two α-globin gene deletions by isoelectric focusing electrophoresis.},
  author={Archana M. Agarwal and Roberto H Nussenzveig and Carolyn Hoke and Thomas S. Lorey and Dina N. Greene},
  journal={American journal of clinical pathology},
  year={2013},
  volume={140 3},
  pages={301-5}
}
OBJECTIVES To investigate the utility of isoelectric focusing electrophoresis (IEF) for identifying patients with α-thalassemia, which results from the deletion of 1 or more of the α-globin genes. METHODS Samples were selected based on their hemoglobin H (HbH) concentration observed using IEF. The samples were analyzed for the most common α-globin gene deletions using molecular analysis. RESULTS α-Globin gene deletions corresponding to α-thalassemia trait or silent carrier were observed in… CONTINUE READING