Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.

@article{Yang2006IdentificationOO,
  title={Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.},
  author={Rong-Ze Yang and M D Lee and Hong Jie Hu and Jessica Pray and Hai-bin Wu and B. C. Hansen and Alan R. Shuldiner and Susan K. Fried and John Mclenithan and Da-Wei Gong},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={290 6},
  pages={E1253-61}
}
Central (visceral) obesity is more closely associated with insulin resistance, type 2 diabetes, and cardiovascular disease than is peripheral [subcutaneous (sc)] obesity, but the underlying mechanism for this pathophysiological difference is largely unknown. To understand the molecular basis of this difference, we sequenced 10,437 expressed sequence tags (ESTs) from a human omental fat cDNA library and discovered a novel visceral fat depot-specific secretory protein, which we have named omentin… CONTINUE READING
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