Identification of nucleolus-localized PTEN and its function in regulating ribosome biogenesis

Abstract

The tumor suppressor PTEN is a lipid phosphatase that is found mutated in different types of human cancers. PTEN suppresses cell proliferation by inhibiting the PI3K-Akt signaling pathway at the cell membrane. However, PTEN is also demonstrated to localize in the cell nucleus where it exhibits tumor suppressive activity via a different, unknown mechanism… (More)
DOI: 10.1007/s11033-014-3518-6

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