Identification of novel variants associated with warfarin stable dosage by use of a two-stage extreme phenotype strategy.

@article{Luo2017IdentificationON,
  title={Identification of novel variants associated with warfarin stable dosage by use of a two-stage extreme phenotype strategy.},
  author={Zhi-ying Luo and Xi Li and Mengyuan Zhu and Jie Tang and Zhi Li and Xiao Zhou and Ge Song and Z Liu and H Zhou and Wei Zhang},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2017},
  volume={15 1},
  pages={
          28-37
        }
}
Essentials Required warfarin doses for mechanical heart valves vary greatly. A two-stage extreme phenotype design was used to identify novel warfarin dose associated mutation. We identified a group of variants significantly associated with extreme warfarin dose. Four novel identified mutations account for 2.2% of warfarin dose discrepancies. SUMMARY Background The variation among patients in warfarin response complicates the management of warfarin therapy, and an improper therapeutic dose… CONTINUE READING

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