Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq

@article{Rubin2016IdentificationON,
  title={Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq},
  author={Ana Rubin and Anna C. Salzberg and Yuka Imamura and Anzor Grivitishvilli and J Tombran-tink},
  journal={BMC Genomics},
  year={2016},
  volume={17}
}
BackgroundDiabetic nephropathy (DN) is a major complication of type1 and type 2 diabetes. Understanding how diabetes regulate transcriptome dynamics in DN is important for understanding the biology of the disease and for guiding development of new treatments.ResultsWe analyzed the kidney transcriptome of a DN mouse model, D2.B6-Ins2Akita/MatbJ, before/after treatment with P78-PEDF. Age, weight, and gender-matched mice and wild-type (wt) littermates were treated at 6 weeks (early treatment) or… 
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The results indicate widespread methylation differences in DKD kidneys and highlights epigenetic changes in the TNF locus and its contribution to the development of nephropathy in patients with diabetes mellitus.
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Tbc1d4, Acadl, Acsl1 and Fabp4 were found to be associated with early diabetes in GK rats for the first time, which may provide a new scope for pathogenesis of postprandial hyperglycemia.
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