Identification of novel target genes by an epigenetic reactivation screen of renal cancer.

@article{Caceres2006IdentificationON,
  title={Identification of novel target genes by an epigenetic reactivation screen of renal cancer.},
  author={Inmaculada Ibanez de Caceres and Essel A Dulaimi and Amanda M. Hoffman and T Al-saleem and Robert G. Uzzo and Paul M. Cairns},
  journal={Cancer research},
  year={2006},
  volume={66 10},
  pages={5021-8}
}
Aberrant promoter hypermethylation is a common mechanism for inactivation of tumor suppressor genes in cancer cells. To generate a global profile of genes silenced by hypermethylation in renal cell cancer (RCC), we did an expression microarray-based analysis of genes reactivated in the 786-0, ACHN, HRC51, and HRC59 RCC lines after treatment with the demethylating drug 5-aza-2 deoxycytidine and histone deacetylation inhibiting drug trichostatin A. Between 111 to 170 genes were found to have at… CONTINUE READING
3 Citations
44 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Similar Papers

Loading similar papers…