Identification of novel synthetic toll-like receptor 2 agonists by high throughput screening.

  title={Identification of novel synthetic toll-like receptor 2 agonists by high throughput screening.},
  author={Yue Guan and Katherine Omueti-Ayoade and Sarita K Mutha and Paul J. Hergenrother and Richard I. Tapping},
  journal={The Journal of biological chemistry},
  volume={285 31},
Toll-like receptors (TLRs) play a central role in host defense by inducing inflammatory and adaptive immune responses following infection. Drugs that target TLRs are of considerable interest as potential inflammatory regulators, vaccine adjuvants, and novel immunotherapeutics. TLR2, in cooperation with either TLR1 or TLR6, mediates responses to a wide variety of microbial products as well as products of host tissue damage. In an effort to understand the structural basis of TLR2 recognition and… CONTINUE READING
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