Identification of novel survivin-derived CTL epitopes.

  title={Identification of novel survivin-derived CTL epitopes.},
  author={Sine Reker and Anders Meier and Lars Holten-Andersen and Inge Marie Svane and J{\"u}rgen C Becker and Per Thor Straten and Mads Hald Andersen},
  journal={Cancer biology & therapy},
  volume={3 2},
The identification of tumor antigens, which are essential for the survival of tumor cells is a new avenue to prevent antigen loss variants emerging due to immunoselection, particularly during immune therapy. In the search for such immunogenic tumor antigens, we recently identified spontaneous cytotoxic lymphocyte (CTL) responses against the inhibitor of apoptosis protein survivin. Thus, we identified two HLA-A2-restricted, survivin-derived CTL epitopes, which both were targets for spontaneous… CONTINUE READING
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