Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif

@article{Kim2007IdentificationON,
  title={Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif},
  author={Minseong Kim and Hyun-Ju Kim and Alexandra Lynne Brown and M Lee and Yoe-Sik Bae and Joo-In Park and Jong-Young Kwak and Jay H. Chung and Jeanho Yun},
  journal={Experimental & Molecular Medicine},
  year={2007},
  volume={39},
  pages={205-212}
}
Checkpoint kinase 1 (Chk1) and Chk2 are effector kinases in the cellular DNA damage response and impairment of their function is closely related to tumorigenesis. Previous studies revealed several substrate proteins of Chk1 and Chk2, but identification of additional targets is still important in order to understand their tumor suppressor functions. In this study, we screened novel substrates for Chk1 and Chk2 using substrate target motifs determined previously by an oriented peptide library… CONTINUE READING
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