Identification of novel sphingolipid-binding motifs in mammalian membrane proteins.

@article{Bjrkholm2014IdentificationON,
  title={Identification of novel sphingolipid-binding motifs in mammalian membrane proteins.},
  author={Patrik Bj{\"o}rkholm and Andreas Ernst and Moritz Hacke and Felix Theodor Wieland and Britta Bruegger and Gunnar von Heijne},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1838 8},
  pages={2066-70}
}
Specific interactions between transmembrane proteins and sphingolipids is a poorly understood phenomenon, and only a couple of instances have been identified. The best characterized example is the sphingolipid-binding motif VXXTLXXIY found in the transmembrane helix of the vesicular transport protein p24. Here, we have used a simple motif-probability algorithm (MOPRO) to identify proteins that contain putative sphingolipid-binding motifs in a dataset comprising proteomes from mammalian… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Statistical analysis of amino acid patterns in transmembrane helices: theGxxxGmotif occurs frequently and inassociation with b-branched residues at neighboring positions

  • A. Senes, M. Gerstein, M. Donald, J. Engelman
  • Mol. Biol. 296
  • 2000
Highly Influential
3 Excerpts

E

  • C.J.A. Sigrist
  • de Castro, L. Cerutti, B.A. Cuche, N. Hulo, A…
  • 2012
1 Excerpt

Z

  • F. Limin, N. Beifang
  • Zhengwei,W. Sitao, L.Weizhong, CD-HIT…
  • 2012
2 Excerpts

Similar Papers

Loading similar papers…