Identification of novel small RNAs using comparative genomics and microarrays.

@article{Wassarman2001IdentificationON,
  title={Identification of novel small RNAs using comparative genomics and microarrays.},
  author={Karen Montzka Wassarman and Francis Repoila and Carsten Rosenow and Gisela Storz and Susan Gottesman},
  journal={Genes & development},
  year={2001},
  volume={15 13},
  pages={1637-51}
}
A burgeoning list of small RNAs with a variety of regulatory functions has been identified in both prokaryotic and eukaryotic cells. However, it remains difficult to identify small RNAs by sequence inspection. We used the high conservation of small RNAs among closely related bacterial species, as well as analysis of transcripts detected by high-density oligonucleotide probe arrays, to predict the presence of novel small RNA genes in the intergenic regions of the Escherichia coli genome. The… CONTINUE READING
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