Identification of novel putative regulators of the major apoptotic nuclease DNA Fragmentation Factor.

@article{Hanus2010IdentificationON,
  title={Identification of novel putative regulators of the major apoptotic nuclease DNA Fragmentation Factor.},
  author={Jakub Hanus and Magdalena Kalinowska-Herok and Piotr Widlak},
  journal={Acta biochimica Polonica},
  year={2010},
  volume={57 4},
  pages={521-7}
}
Yeast two- and three-hybrid systems were used to screen cDNA libraries from HeLa cells and human brain tissue to identify novel protein partners of DNA Fragmentation Factor, the major apoptotic nuclease. The two-hybrid system revealed the DFF45 inhibitory subunit of the nuclease as the only identified partner of the DFF40 catalytic subunit. Similar analysis revealed several protein candidates that potentially interact with the DFF45 subunit: FBXO28, FOSL1, PGK1, PCNT, FHL1 and GFAP. Recombinant… CONTINUE READING

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