Identification of novel potent inhibitors against Bcl-xL anti-apoptotic protein using docking studies.

@article{Shipra2012IdentificationON,
  title={Identification of novel potent inhibitors against Bcl-xL anti-apoptotic protein using docking studies.},
  author={G. Shipra and Misra Gauri and Pant Mohan Chandra and Seth Prahlad Kishore},
  journal={Protein and peptide letters},
  year={2012},
  volume={19 12},
  pages={
          1302-17
        }
}
  • G. Shipra, Misra Gauri, +1 author Seth Prahlad Kishore
  • Published 2012
  • Medicine, Biology
  • Protein and peptide letters
  • Bcl-xL protein belongs to BCL-2 family which has either pro- or anti-apoptotic activities owing to their importance in the regulation of apoptosis, tumor genesis and cellular responses to anti-cancer therapy. Bcl-xL permeabilize the outer mitochondrial membrane of cells and inhibit these processes. Protein-inhibitor interactions play an important role in regulating the expression of Bcl-xL protein. Here, we report the docking studies that resulted in the identification of new inhibitors… CONTINUE READING
    8 Citations
    Understanding the Interactions of High-Mobility Group of Protein Domain B1 with DNA Adducts Generated by Platinum Anticancer Molecules Using In Silico Approaches
    Bio/chemoinformatics in India: an outlook
    • 6
    • PDF

    References

    SHOWING 1-10 OF 33 REFERENCES
    Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
    • 228
    Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins
    • 54
    • Highly Influential
    • PDF
    Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
    • 46
    Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol.
    • 13
    • Highly Influential
    Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists.
    • 26
    The BCL-2 protein family: opposing activities that mediate cell death
    • 3,751
    • PDF
    Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax
    • 262
    • PDF
    Apoptosis: clinical relevance and pharmacological manipulation.
    • 102