Identification of novel potent inhibitors against Bcl-xL anti-apoptotic protein using docking studies.

  title={Identification of novel potent inhibitors against Bcl-xL anti-apoptotic protein using docking studies.},
  author={G. Shipra and Misra Gauri and Pant Mohan Chandra and Seth Prahlad Kishore},
  journal={Protein and peptide letters},
  volume={19 12},
  • G. Shipra, Misra Gauri, +1 author Seth Prahlad Kishore
  • Published 2012
  • Medicine, Biology
  • Protein and peptide letters
  • Bcl-xL protein belongs to BCL-2 family which has either pro- or anti-apoptotic activities owing to their importance in the regulation of apoptosis, tumor genesis and cellular responses to anti-cancer therapy. Bcl-xL permeabilize the outer mitochondrial membrane of cells and inhibit these processes. Protein-inhibitor interactions play an important role in regulating the expression of Bcl-xL protein. Here, we report the docking studies that resulted in the identification of new inhibitors… CONTINUE READING
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