Identification of novel mutations by exome sequencing in African American colorectal cancer patients.

@article{Ashktorab2015IdentificationON,
  title={Identification of novel mutations by exome sequencing in African American colorectal cancer patients.},
  author={Hassan Ashktorab and Mohammad R Daremipouran and Joe M Devaney and S. Sunil Varma and Hamed Rahi and Edward Lee and Babak Shokrani and Russell Schwartz and Michael L. Nickerson and Hassan Brim},
  journal={Cancer},
  year={2015},
  volume={121 1},
  pages={34-42}
}
BACKGROUND The purpose of this study was to identify genome-wide single nucleotide variants and mutations in African American patients with colorectal cancer (CRC). There is a need of such studies in African Americans, because they display a higher incidence of aggressive CRC tumors. METHODS We performed whole exome sequencing (WES) on DNA from 12 normal/tumor pairs of African American CRC patient tissues. Data analysis was performed using the software package GATK (Genome Analysis Tool Kit… CONTINUE READING
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