Identification of novel metabolites of prostaglandin E2 formed by isolated rat hepatocytes.

@article{Hankin1997IdentificationON,
  title={Identification of novel metabolites of prostaglandin E2 formed by isolated rat hepatocytes.},
  author={Joseph A. Hankin and Pat Wheelan and Robert C Murphy},
  journal={Archives of biochemistry and biophysics},
  year={1997},
  volume={340 2},
  pages={
          317-30
        }
}
The metabolism of prostaglandin E2 (PGE2) in isolated rat hepatocytes led to the formation of four major as well as several minor products which were structurally characterized using electrospray tandem mass spectrometry. The major metabolites identified included dinor-PGE1, dinor-PGE2, and tetranor-PGE1 and the taurine conjugates of dinor-PGE1 and dinor-PGE2. Several minor metabolites including the taurine conjugates of PGE2 and tetranor PGE1 along with a glucuronide conjugate of PGE2 were… CONTINUE READING

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