Identification of novel metabolites from Aspergillus flavus by high resolution and multiple stage mass spectrometry

@article{Malysheva2014IdentificationON,
  title={Identification of novel metabolites from Aspergillus flavus by high resolution and multiple stage mass spectrometry},
  author={Svetlana V. Malysheva and Natalia Arroyo-Manzanares and Jeffrey W. Cary and Kenneth C. Ehrlich and Julie Vanden Bussche and Lynn Vanhaecke and Deepak Bhatnagar and Jos{\'e} Diana di Mavungu and Sarah de Saeger},
  journal={Food Additives \& Contaminants: Part A},
  year={2014},
  volume={31},
  pages={111 - 120}
}
The filamentous fungus Aspergillus flavus is one of the most important species in the Aspergillus genus and is distributed worldwide as a prevalent aflatoxin-producing food and feed contaminant. A. flavus contains more than 55 gene clusters that are predicted to encode proteins involved in secondary metabolite production. One of these, cluster 27, contains a polyketide synthase (pks27) gene that encodes a protein that is highly homologous to the aflatoxin cluster PKS. Comparative metabolomics… 
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Results confirm the monophyly of A. korhogoensis, and strengthen its position in the A. flavus clade, as the sister taxon of Aspergillus parvisclerotigenus.
The Aspergilli and Their Mycotoxins: Metabolic Interactions With Plants and the Soil Biota
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The role of mycotoxin producing Aspergillus species and their interactions in the ecosystem are discussed and the complexity of the roles of the main toxic secondary metabolites as well as their fate in natural environments and agriculture is highlighted.
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