Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer.


The genome of a subset of non-small-cell lung cancers (NSCLC) harbors a small inversion within chromosome 2 that gives rise to a transforming fusion gene, EML4-ALK, which encodes an activated protein tyrosine kinase. Although breakpoints within EML4 have been identified in introns 13 and 20, giving rise to variants 1 and 2, respectively, of EML4-ALK, it has… (More)
DOI: 10.1158/0008-5472.CAN-07-6158


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