Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death.

@article{Slater2013IdentificationON,
  title={Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death.},
  author={Louise H Slater and Erik C Hett and Kevin Mark and Nicole M. Chumbler and Deepa K Patel and D Borden Lacy and Robert J. Collier and Deborah T Hung},
  journal={ACS chemical biology},
  year={2013},
  volume={8 4},
  pages={812-22}
}
Studying how pathogens subvert the host to cause disease has contributed to the understanding of fundamental cell biology. Bacillus anthracis, the causative agent of anthrax, produces the virulence factor lethal toxin to disarm host immunity and cause pathology. We conducted a phenotypic small molecule screen to identify inhibitors of lethal toxin-induced macrophage cell death and used an ordered series of secondary assays to characterize the hits and determine their effects on cellular… CONTINUE READING
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