Identification of novel helper epitope peptides of Survivin cancer-associated antigen applicable to developing helper/killer-hybrid epitope long peptide cancer vaccine.

@article{Ohtake2014IdentificationON,
  title={Identification of novel helper epitope peptides of Survivin cancer-associated antigen applicable to developing helper/killer-hybrid epitope long peptide cancer vaccine.},
  author={Junya Ohtake and Takayuki Ohkuri and Yuji Togashi and Hidemitsu Kitamura and Kiyotaka Okuno and Takashi Nishimura},
  journal={Immunology letters},
  year={2014},
  volume={161 1},
  pages={20-30}
}
We identified novel helper epitope peptides of Survivin cancer antigen, which are presented to both HLA-DRB1*01:01 and DQB1*06:01. The helper epitope also contained three distinct Survivin-killer epitopes presented to HLA-A*02:01 and A*24:02. This 19 amino-acids epitope peptide (SU18) induced weak responses of Survivin-specific CD4(+) and CD8(+) T cells though it contained both helper and killer epitopes. To enhance the vaccine efficacy, we synthesized a long peptide by conjugating SU18 peptide… CONTINUE READING
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