Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach.

@article{Tozlu2006IdentificationON,
  title={Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach.},
  author={Seng{\"u}l Tozlu and Igor Girault and Sophie Vacher and Julie A. Vendrell and Catherine Andrieu and Fr{\'e}d{\'e}rique Spyratos and Pascale A. Cohen and Rosette Lidereau and Ivan Bi{\'e}che},
  journal={Endocrine-related cancer},
  year={2006},
  volume={13 4},
  pages={1109-20}
}
The estrogen receptor alpha (ERalpha) plays a critical role in the pathogenesis and clinical behavior of breast cancer. To obtain further insights into the molecular basis of estrogen-dependent forms of this malignancy, we used real-time quantitative reverse transcription (RT)-PCR to compare the mRNA expression of 560 selected genes in ERalpha-positive and ERalpha-negative breast tumors. Fifty-one (9.1%) of the 560 genes were significantly upregulated in ERalpha-positive breast tumors compared… CONTINUE READING
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