Identification of novel genes associated with HIV-1 latency by analysis of histone modifications

  title={Identification of novel genes associated with HIV-1 latency by analysis of histone modifications},
  author={Kyung-Chang Kim and S. Lee and Junseock Son and Younghyun Shin and C. Yoon and C. Kang and Byeong-Sun Choi},
  journal={Human Genomics},
  • Kyung-Chang Kim, S. Lee, +4 authors Byeong-Sun Choi
  • Published 2017
  • Biology, Medicine
  • Human Genomics
  • BackgroundA reservoir of HIV-1 is a major obstacle in eliminating HIV-1 in patients because it can reactivate in stopping antiretroviral therapy (ART). Histone modifications, such as acetylation and methylation, play a critical role in the organization of chromatin domains and the up- or downregulation of gene expression. Although many studies have reported that an epigenetic mechanism is strongly involved in the maintenance of HIV-1 transcriptional latency, neither the epigenetic control of… CONTINUE READING
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