Identification of novel functional TBP‐binding sites and general factor repertoires

  title={Identification of novel functional TBP‐binding sites and general factor repertoires},
  author={S. S. Denissov and Marc A. van Driel and Renate Voit and Maarten L. Hekkelman and Tim Hulsen and Nouria Hernandez and Ingrid Grummt and Ron Wehrens and Hendrik G. Stunnenberg},
  journal={The EMBO Journal},
Our current knowledge of the general factor requirement in transcription by the three mammalian RNA polymerases is based on a small number of model promoters. Here, we present a comprehensive chromatin immunoprecipitation (ChIP)‐on‐chip analysis for 28 transcription factors on a large set of known and novel TATA‐binding protein (TBP)‐binding sites experimentally identified via ChIP cloning. A large fraction of identified TBP‐binding sites is located in introns or lacks a gene/mRNA annotation… 
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