Identification of novel extracellular signal-regulated kinase docking domain inhibitors.

  title={Identification of novel extracellular signal-regulated kinase docking domain inhibitors.},
  author={Chad N Hancock and Alba T. Macias and Eun Kyoung Lee and Su Yeon Yu and Alexander D. MacKerell and Paul Shapiro},
  journal={Journal of medicinal chemistry},
  volume={48 14},
The extracellular signal regulated kinase (ERK1 and ERK2) signal transduction pathways play a critical role in cell proliferation. Hyperactivation of the ERK proteins either through increased expression of membrane-bound growth factor receptors or genetic mutations of upstream proteins is thought to be involved in the pathogenesis of many human cancers. Thus, targeted inhibition of ERK signaling is viewed as a potential approach to prevent cancer cell proliferation. Currently, no specific… CONTINUE READING

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