Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors.

@article{Chen2008IdentificationON,
  title={Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors.},
  author={Jian-kang Chen and Jianchun Chen and John D. Imig and Shouzuo Wei and David L. Hachey and Jagadeesh Setti Guthi and John R Falck and J. Capdevila and Raymond C Harris},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 36},
  pages={24514-24}
}
Arachidonic acid is an essential constituent of cell membranes that is esterified to the sn-2-position of glycerophospholipids and is released from selected lipid pools by phospholipase cleavage. The released arachidonic acid can be metabolized by three enzymatic pathways: the cyclooxygenase pathway forming prostaglandins and thromboxanes, the lipoxygenase pathway generating leukotrienes and lipoxins, and the cytochrome P450 (cP450) pathway producing epoxyeicosatrienoic acids and… CONTINUE READING

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