Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity.

@article{Wiebe2003IdentificationON,
  title={Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity.},
  author={Matthew S. Wiebe and Tamara K Nowling and Angie Rizzino},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 20},
  pages={17901-11}
}
Sox transcription factors play key regulatory roles throughout development, binding DNA through a consensus (A/T)(A/T)CAA(A/T)G sequence. Although many different Sox proteins bind to this sequence, it has been observed that gene regulatory elements are commonly responsive to only a small subset of the entire family, implying that regulatory mechanisms exist to permit selective DNA binding and/or transactivation by Sox family members. To identify and explore the mechanisms modulating gene… CONTINUE READING