Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening.

@article{Hirayama2007IdentificationON,
  title={Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening.},
  author={Kazunori Hirayama and Shunsuke Aoki and Kaori Nishikawa and Takashi Matsumoto and Keiji Wada},
  journal={Bioorganic & medicinal chemistry},
  year={2007},
  volume={15 21},
  pages={6810-8}
}
UCH-L3 (ubiquitin C-terminal hydrolase-L3) is a de-ubiquitinating enzyme that is a component of the ubiquitin-proteasome system and known to be involved in programmed cell death. A previous study of high-throughput drug screening identified an isatin derivative as a UCH-L3 inhibitor. In this study, we attempted to identify a novel inhibitor with a different structural basis. We performed in silico structure-based drug design (SBDD) using human UCH-L3 crystal structure data (PDB code; 1XD3) and… CONTINUE READING