Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations.

@article{Rampersaud2007IdentificationON,
  title={Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations.},
  author={Evadnie Rampersaud and Coleen Mae Damcott and Mao Fu and Haiqing Shen and Patrick McArdle and Xiaolian Shi and J. Richard Shelton and Jing Bo Yin and Yen-Pei Christy Chang and Sandra H. Ott and Li Zhang and Yiju Zhao and Braxton D. Mitchell and Jeffery R. O'Connell and Alan R. Shuldiner},
  journal={Diabetes},
  year={2007},
  volume={56 12},
  pages={
          3053-62
        }
}
OBJECTIVE We sought to identify type 2 diabetes susceptibility genes through a genome-wide association scan (GWAS) in the Amish. RESEARCH DESIGN AND METHODS DNA from 124 type 2 diabetic case subjects and 295 control subjects with normal glucose tolerance were genotyped on the Affymetrix 100K single nucleotide polymorphism (SNP) array. A total of 82,485 SNPs were tested for association with type 2 diabetes. Type 2 diabetes-associated SNPs were further prioritized by the following: 1… CONTINUE READING

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