Identification of novel bone-specific molecular targets of binge alcohol and ibandronate by transcriptome analysis.

@article{Himes2008IdentificationON,
  title={Identification of novel bone-specific molecular targets of binge alcohol and ibandronate by transcriptome analysis.},
  author={Ryan D Himes and Frederick H. Wezeman and John J. Callaci},
  journal={Alcoholism, clinical and experimental research},
  year={2008},
  volume={32 7},
  pages={1167-80}
}
BACKGROUND Our laboratory established that binge alcohol-related bone damage is prevented by aminobisphosphonates, suggesting bone resorption increases following binge exposure. We examined the effects of binge alcohol and antiresorptive therapy on the relationship between bone damage and modulation of the vertebral transcriptome, in an attempt to determine how alcohol-induced bone damage and its prevention modulate bone-related biological pathways. METHODS Male Sprague-Dawley rats were… CONTINUE READING

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