Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis.

@article{Xolalpa2007IdentificationON,
  title={Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis.},
  author={Wendy Xolalpa and Antonio Vallecillo and Martha Lara and Guillermo Mendoza-Hern{\'a}ndez and Marcelo Comini and Ralf Spallek and Mahavir Singh and C. Helbert Eduardo Espitia},
  journal={Proteomics},
  year={2007},
  volume={7 18},
  pages={3332-41}
}
Binding and activation of human plasminogen (Plg) to generate the proteolytic enzyme plasmin (Plm) have been associated with the invasive potential of certain bacteria. In this work, proteomic analysis together with ligand blotting assays identified several major Plg-binding spots in Mycobacterium tuberculosis soluble extracts (SEs) and culture filtrate proteins. The identity of 15 different proteins was deduced by N-terminal and/or MS and corresponded to DnaK, GroES, GlnA1, Ag85 complex, Mpt51… CONTINUE READING