Identification of novel antimicrobials using a live-animal infection model.

  title={Identification of novel antimicrobials using a live-animal infection model.},
  author={Terence I. Moy and Anthony R. Ball and Zafia Anklesaria and Gabriele Casadei and Kim Lewis and Frederick M. Ausubel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 27},
The alarming increase of antibiotic-resistant bacterial pathogens points to the need for novel therapeutic approaches to combat infection. To discover novel antimicrobials, we devised a screen to identify compounds that promoted the survival of the model laboratory nematode Caenorhabditis elegans infected with the human opportunistic pathogen Enterococcus faecalis. E. faecalis colonizes the nematode intestinal tract, forming a persistent lethal infection. Infected nematodes were rescued by… CONTINUE READING

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