Identification of novel antigens within the Schistosoma japonicum tetraspanin family based on molecular characterization.

@article{Wu2011IdentificationON,
  title={Identification of novel antigens within the Schistosoma japonicum tetraspanin family based on molecular characterization.},
  author={Wei Wu and Pengfei Cai and Qijun Chen and Heng Wang},
  journal={Acta tropica},
  year={2011},
  volume={117 3},
  pages={216-24}
}
Tetraspanins (TSPs) are proteins found on the surface of the parasite Schistosoma mansoni that have been regarded as potential protective antigens. However, divergent evolution may occur among the species of S. mansoni and Schistosoma japonicum under different environmental pressure. Thus, it was essential to characterize the S. japonicum TSP family members before selecting potential candidate TSP antigens. In this study, we used bioinformatics and experimental validation to investigate 29 TSP… CONTINUE READING