Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.

@article{Capelli2010IdentificationON,
  title={Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.},
  author={Anna Maria Capelli and Laura Castelletti and Cristian M Salvagno and Beatrice Oliosi and Elisa Di Lenarda and Caterina Virginio and Andrew Lightfoot and James N. C. Kew and Simon Teague},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 15},
  pages={4561-5}
}
The pharmacophore model of in house potent and selective alpha7 nAChR positive allosteric modulators is reported. The model was used to fish out commercially-available compounds from corporate 3D databases. As a result, novel alpha7 positive modulator chemotypes were identified. A rat full PK profile of a representative compound is also described. 

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